Synthesis of Some Novel Sulfonamides Containing Biologically Active Alkanoic Acid, Acetamide, Thiazole, and Pyrrole Moieties of Expected Antitumor and Radiosensitizing Activities
نویسندگان
چکیده
Several novel N substituted sulfapyridine derivatives were synthesized by condensation of 2-ChloroN-(4-(N-pyridin-2-ylsulfamoyl)phenyl) acetamide 2 with different amino acids, amines, malononitrile, or ammonium thiocyanate to yield the corresponding alkanoic acid derivatives 3a-f, acetamide derivatives 48, pyrrole derivatives 912, and thiazolidinone derivative 13. The newly synthesized compounds were screened in-vitro against human breast cancer cell line (MCF-7). Compounds 3b, 10 and 12 showed the highest activity with IC50 values 26.1, 22.4, 22.1 μM compared to doxorubicin as a reference drug. The promising compounds 3b, 10 and 12 showed the ability to sensitize cancer cells to the lethal effects of ionizing radiation.
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